abstract：WHAT IS KNOWN AND OBJECTIVE:Neuraminidase inhibitors are important options for the treatment of infection by the influenza virus. For the treatment of severe influenza, parenteral administration of a neuraminidase inhibitor may be desirable. This study was conducted to evaluate the pharmacokinetic and safety profiles o...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Shida Y,Hara K,Nohda S,Soutome T,Hirama T

更新日期：2013-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Colchicine is an anti-inflammatory agent used primarily in treatment of gout and familial Mediterranean fever. Toxicity is uncommon, and depends on dose, hepatic or renal impairment, co-administration with P-glycoprotein or CYP3A4 inhibitors and route of administration. In patients taking p-...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Abodunde OA,LevakaVeera RR,Desai R,Nweke N,Berrou M

更新日期：2013-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Demonstration of the utility of electronic medical records (EMRs) for pharmacovigilance (PV) has been highly anticipated. Analysis using appropriately selected EMRs should enable accurate estimation of adverse drug event (ADE) frequencies and thus promote appropriate regulatory actions. Stat...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Sai K,Hanatani T,Azuma Y,Segawa K,Tohkin M,Omatsu H,Makimoto H,Hirai M,Saito Y

更新日期：2013-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Admixtures of levobupivacaine, fentanyl and epinephrine are increasingly used in epidural pain management. Neither the compatibility nor the stability of levobupivacaine with fentanyl and epinephrine is known and therefore we examined the chemical, physical and microbiological stability of l...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Helin-Tanninen M,Lehtonen M,Naaranlahti T,Venäläinen T,Pentikäinen J,Laatikainen A,Kokki H

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Auron Misheil therapy (AMT) is a combination of widely used pharmaceuticals and herbal components that has been used since the 1980s as a supportive therapy, mainly in end-stage cancer patients on a compassionate basis. This phase I study was conducted to assess the safety, tolerability, and ph...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Scheele J,Diergarten K,Drevs J,Niazi FR

更新日期：2013-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The most common complication of heparin therapy is bleeding. Allergic reactions to heparin are rare, and the mechanisms are poorly understood. We report on a case of acute systemic reaction after subcutaneous injections of a low-molecular-weight heparin (LMWH) in a patient with a genetic pre...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Leone S,Zuccoli ML,Fucile C,Storace S,Martelli A,Mattioli F

更新日期：2012-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:There is increasing evidence that epigenetics plays a major role in the pathogenesis of the idiopathic mental disorders. This article comments on the role of epigenetics in the pharmacotherapy, psychotherapy and nutritional management of these disorders. COMMENT:There are two classes of epi...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Peedicayil J

更新日期：2012-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The major clinical complication of statins is a variety of muscle complaints ranging from myalgia to rhabdomyolysis. There is growing evidence that carriers of genetic polymorphisms in the enzymes and transporters implicated in statin disposition, particularly the SLCO1B1 gene, are at increa...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Francesca Notarangelo M,Marziliano N,Antonietta Demola M,Pigazzani F,Guidorossi A,Angelica Merlini P,Ardissino D

更新日期：2012-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF) that has activity in several types of malignancies. One of the uncommon adverse effects is spontaneous bowel perforation. In patients who have undergone cystectomy, a loop of small bowel is often used...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Liu SV,Gollard R,Iqbal S

更新日期：2012-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:ABT-594 is a non-opioid, non-NSAID analgesic. The objective of this work was to characterize the population pharmacokinetics of ABT-594 in subjects with neuropathic pain. METHODS:Efficacy, safety and pharmacokinetics of ABT-594 in subjects with painful diabetic polyneuropathy were evaluated...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Dutta S,Awni W

更新日期：2012-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:CYP2C19*17 allele increases the metabolic activity of CYP2C19 resulting in decreased therapeutic levels of CYP2C19 substrates. There exist inter-ethnic differences in the distribution of this allele. The present study was aimed at establishing the allele and genotype frequencies of CYP2C19*1...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Anichavezhi D,Chakradhara Rao US,Shewade DG,Krishnamoorthy R,Adithan C

更新日期：2012-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The potential beneficial therapeutic effects of cannabinoid CB₁ receptor antagonists or partial agonists have driven drug discovery and development efforts and have led to clinical candidates. It is generally assumed that these compounds are CB₁ 'selective' and produce their effects exclusiv...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Raffa RB,Ward SJ

更新日期：2012-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Fluconazole is an antifungal agent that is commonly used to treat patients with serious systemic fungal infections in intensive care units. Fosfluconazole is a phosphate prodrug of fluconazole, which was developed to reduce the volume of fluid required to administer fluconazole by intravenou...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Aoyama T,Hirata K,Hirata R,Yamazaki H,Yamamoto Y,Hayashi H,Matsumoto Y

更新日期：2012-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Adherence to evidence-based drug therapy after acute myocardial infarction has increased over the last decades, but is still unsatisfactory. Our objectives are to set out to analyse patterns of evidence-based drug therapy after acute myocardial infarction (AMI), and evaluating socio-demograp...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Kirchmayer U,Agabiti N,Belleudi V,Davoli M,Fusco D,Stafoggia M,Arcà M,Barone AP,Perucci CA

更新日期：2012-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Tumour necrosis factor-α (TNF-α)-blocking agents are increasingly used in the management of refractory rheumatoid arthritis (RA). Although effective, they are associated with rare but potentially fatal adverse effects, including interstitial lung disease (ILD). In patients with pre-existing ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Horai Y,Miyamura T,Shimada K,Takahama S,Minami R,Yamamoto M,Suematsu E

更新日期：2012-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Imatinib is a specific BCR/ABL inhibitor, commonly used for the treatment of chronic myeloid leukaemia (CML), a hematological malignancy resulting from a chromosomal translocation that generates the BCR/ABL fusion protein. Recent studies showed that the imatinib has cytotoxic and apoptotic e...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Baran Y,Zencir S,Cakir Z,Ozturk E,Topcu Z

更新日期：2011-12-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Upper respiratory tract infections (URTI) frequently cause exacerbations of chronic-obstructive pulmonary disease (COPD). Stimulation of the innate immune system may provide an early defence against such infections. The objective of this study was to determine whether Echinacea purpurea (EP)...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Isbaniah F,Wiyono WH,Yunus F,Setiawati A,Totzke U,Verbruggen MA

更新日期：2011-10-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Patients suffering from renal dysfunction often have multiple medical conditions either as a cause or as a consequence of their renal disease. These patients receive an average of 10-12 medications daily leading to complex dosing schedules and are more likely to develop medication-related pr...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Castelino RL,Sathvik BS,Parthasarathi G,Gurudev KC,Shetty MS,Narahari MG

更新日期：2011-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Far more patients are now surviving cancer than ever before because of major advances in the diagnosis and treatment of primary and metastatic malignancy. Adjuvant chemotherapeutic drug and combination regimens have contributed to the success. However, persistent residual adverse effects inv...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Raffa RB

更新日期：2011-08-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:The complexity and diversity of irritable bowel syndrome's (IBS) presentation make treatment difficult. Although there are reviews and guidelines for treating IBS, they focus on the efficacy of medications for IBS symptoms using high-priority endpoints, leaving those of lower priority largel...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Trinkley KE,Nahata MC

更新日期：2011-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVES:Subjects of different ethnic groups may respond differently to drugs. The present study was conducted to compare the oral pharmacokinetics of midazolam among healthy volunteers from five different ethnic groups in China: Han, Mongolian, Uygur, Hui and Korean. METHODS:Healthy volunteers (10...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Guo T,Mao GF,Xia DY,Su XY,Zhao LS

更新日期：2011-06-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone (ciclopirox) and specifically its olamine salt 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone 2-aminoethanol salt (ciclopirox olamine) are anti-fungal agents currently used for the treatment of mild to moderate cutaneous fungal infection. Our ob...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Weir SJ,Patton L,Castle K,Rajewski L,Kasper J,Schimmer AD

更新日期：2011-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Tacrolimus, a widely used immunosuppressive agent in organ transplantation, has a narrow therapeutic window. It has been suggested that its interaction with lansoprazole could be dependent on polymorphisms of CYP3A5 and CYP2C19. The objective of this study was to investigate how, 1 year afte...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Miura M,Niioka T,Kagaya H,Saito M,Hayakari M,Habuchi T,Satoh S

更新日期：2011-04-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Lowering haemoglobin A(₁c) (HbA(₁c)) has clearly been shown to reduce microvascular complications of diabetes and possibly macrovascular disease and vitamin E has been suggested as a possibly useful intervention. Our aim is to evaluate the effect of vitamin E supplementation on glycaemic con...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Suksomboon N,Poolsup N,Sinprasert S

更新日期：2011-02-01 00:00:00

abstract：WHAT IS KNOWN AND OBJECTIVE:Serum sialic acid is a recently investigated potential risk-marker for cardiovascular complications. There is a known association between sialic acid and cardiovascular complications in diabetes mellitus. We aimed to investigate the effect of antidiabetic drugs on the serum concentration of ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Rahman IU,Malik SA,Bashir M,Khan RU,Idrees M

更新日期：2010-12-01 00:00:00

abstract：WHAT IS KNOWN:The increased risk of cardiovascular events in diabetic patients has been related to numerous metabolic and haemoreological factors. Some of these factors appear to be particularly evident during the post-prandial phases and to be related to peak plasma glucose level. AIM:To compare the effect of additio...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Derosa G,Mereu R,D'Angelo A,Salvadeo SA,Ferrari I,Fogari E,Gravina A,Palumbo I,Maffioli P,Randazzo S,Cicero AF

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Epilepsy is a disease requiring chronic therapy with antiepileptic drugs (AEDs). Many conventional AEDs currently available have either too rapid an absorption or elimination, requiring the patient to take multiple doses per day, which may adversely impact adherence or cause peak-related side-effects. Conseq...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Reed RC,Meinhold J,Dutta S,Liu W,Qiu Y

更新日期：2010-08-01 00:00:00

abstract：:An imbalance of oxidative-antioxidant defence mechanism has been proposed in systemic lupus erythematosus patients. Co-administration of N-acetylcysteine (NAC) which has a strong antioxidant activity may produce a satisfactory therapeutic outcome when added to standard therapy. We report a case of a 46-year-old lupus ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tewthanom K,Janwitayanujit S,Totemchockcyakarn K,Panomvana Na Ayudhya D

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Acute coronary syndrome (ACS) is a leading cause of death. Correct implementation of evidence-based guidelines should improve outcome. We conducted this study to determine to what extent management of ACS in a tertiary care medical ward in Sri Lanka adhered to current guidelines. STUDY METHOD...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Rajapakse S,Rodrigo PC,Selvachandran J

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The optimal administration of liquid medications requires accurate dose delivery. This is particularly important in the treatment of infants and children, as well as elderly people, who are more sensitive to dosage errors. Previous studies revealed significant dosage inaccuracies with measuring...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Dockhorn S,Feuersenger D,Schuenemann S,Knauf B,Duerr S,Schubert-Zsilavecz M,Abdel-Tawab M

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In our original study based on five monozygotic twin pairs and seven same-sex sib pairs, we previously showed that genetic factors contribute to body weight gain induced by the atypical antipsychotic clozapine. We aim to study this further by including patients treated with the atypical antipsy...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Gebhardt S,Theisen FM,Haberhausen M,Heinzel-Gutenbrunner M,Wehmeier PM,Krieg JC,Kühnau W,Schmidtke J,Remschmidt H,Hebebrand J

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:The aim of this review is to evaluate and summarize the available scientific information on the commonest plant extracts marketed in Western countries. In view of the intense, ongoing search for new plant extracts with powerful anti-inflammatory activity, we paid particular attention to this topic. The aim is...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Cravotto G,Boffa L,Genzini L,Garella D

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To investigate the safety and pharmacokinetics of bromotetrandrine (BrTet, W198), a novel inhibitor of P-glycoprotein (P-gp), after single-dose i.v. infusion in healthy Chinese volunteers. METHODS:We conducted a randomized, dose-escalating, phase I clinical study for that purpose. Thirty healthy subjects rec...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Zheng L,Qing YP,Xu N,Yu Q,Wang Y,Wang FP,Li ZY

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To assess the influence of levodopa on swallowing dysfunction in Parkinson's disease patients. METHODS:A systematic review of the literature and a meta-analysis were performed. All studies referring to levodopa and swallowing dysfunction that provided direct data or data that could be transformed into mean +...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Menezes C,Melo A

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Insomnia is a common complaint in the general population. Interest in the use of alternative treatments for insomnia is increasing exponentially and is fairly common in Taiwan. We undertook a survey to define the drug utilization patterns of Chinese herbal medicines (CM) for insomnia in Taiwan....

journal_title：Journal of clinical pharmacy and therapeutics

authors： Chen LC,Chen IC,Wang BR,Shao CH

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The penetration of generic drugs in the Greek pharmaceutical market is placed among the weakest in the EU. The Greek regulatory framework does not systematically support the development of this subsector and physicians are not provided with incentives for prescribing generics. The aim of this s...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tsiantou V,Zavras D,Kousoulakou H,Geitona M,Kyriopoulos J

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:To estimate the prevalence of potentially severe drug-drug interactions (DDIs) and their relationship with age, sex and number of prescribed drugs. METHODS:We analysed all prescriptions dispensed from 1 January 2003 to 31 December 2003 to individuals aged 65 or more registered under the Local Health Authority ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Nobili A,Pasina L,Tettamanti M,Lucca U,Riva E,Marzona I,Monesi L,Cucchiani R,Bortolotti A,Fortino I,Merlino L,Walter Locatelli G,Giuliani G

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:Renal function was estimated in 129 elderly patients with methicillin-resistant Staphylococcus aureus (MRSA) who were treated with vancomycin (VCM). The estimation was performed by substituting serum creatinine (SCR) measured enzymatically and a value converted using the Jaffe method into the Cockcroft-Gault ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Tsuji Y,Hiraki Y,Mizoguchi A,Sadoh S,Sonemoto E,Kamimura H,Karube Y

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Empirical use of intravenous (IV) itraconazole (ITZ) for febrile neutropenic patients has recently been introduced in Korea. This study was designed to investigate the population pharmacokinetics (PK) of IV-ITZ. METHODS:Sparse PK data were collected from febrile neutropenic patients undergoing empirical ITZ th...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lee DG,Chae H,Yim DS,Park SH,Choi SM,Kim S,Choi JH,Yoo JH,Shin WS

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:In paediatric pharmacotherapy, many drugs are prescribed to be given in ways and for conditions not approved in the marketing authorization (MA). Thus, off-label prescribing of drugs with no MA is widespread in paediatric wards. However, drug MA status and clinical practices differ across countries. In this ...

journal_title：Journal of clinical pharmacy and therapeutics

authors： Lindell-Osuagwu L,Korhonen MJ,Saano S,Helin-Tanninen M,Naaranlahti T,Kokki H

更新日期：2009-06-01 00:00:00